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KMID : 0604520060320040257
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 4 p.257 ~ p.261
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Anti-irritation Effects of Rheum undulatum L. Extract
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Kim Sung-Woo
Kim Hyung-Bae
Lee Kun-Kook
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Abstract
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The aim of this study is to assess the anti-irritation activities of Rheum undulatum L. extract against various irritants. In order to investigate the anti-inflammation effects of Rheum undulatum L. extract on keratinocytes, we measured the quantities of interleukin 8 (IL-8) and tumor necrosis factor {alpha}(TNF {alpha}) secreted by cultured human keratinocytes. As the results, Rheum undulatum L. extract inhibited the secretion of these cytokines dosage-dependently. We also investigated the anti-inflammation effects of Rheum undulatum L. extract against irritant skin reactions induced by 3 mM Methyl nicotinate. The flush was significantly decreased by application of O/W emulsion containing Rheum undulatum L. extract. In the primary irritation test, when Rheum undulatum L. extract was included in O/W emulsion containing 5.0% lactic acid, its considerable anti-irritation effect was revealed. In a in-use test, we confirmed the excellent anti-irritation effect of O/W emulsion containing Rheum undulatum L. extract.
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KEYWORD
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Rheum undulatum L., anti-irritation, cosmetics, IL-8, TNF{\alpha}
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